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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Acetylcysteine and Mitoxantrone

supplement:

Acetylcysteine

drug:

Mitoxantrone

Research Papers that Mention the Interaction

“The effect of mitoxantrone was not significantly modified by nominal absence of extracellular Ca2+ but significantly blunted by the antioxidant N-acetylcysteine (1 mM).”
Mitoxantrone-Induced Suicidal Erythrocyte Death
Cellular Physiology and Biochemistry  •  2014  |  View Paper
“Antioxidant N-acetyl-l-cysteine inhibited the DHA effect on both metabolite accumulation and cell sensitization to MTX.”
Differential Subcellular Distribution of Mitoxantrone in Relation to Chemosensitization in Two Human Breast Cancer Cell Lines
Drug Metabolism and Disposition  •  2007  |  View Paper
“The induction of both ATM activation and H2AX phosphorylation by MXT was prevented to a large extent by N-acetyl-L-cysteine (NAC), a scavenger of reactive oxygen species (ROS).”
Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-Cysteine
Cancer biology & therapy  •  2006  |  View Paper