Possible Interaction: Acetylcysteine and Mitomycin

“Furthermore, the mercapturic acids of ITC are not stable.”

“Here we have demonstrated, using [(14)C]… ITC and [(14)C]sulforaphane, that NAC pretreatment significantly reduces ITC cellular uptake by conjugating with ITCs in the medium, suggesting that reduced uptake of ITCs, rather than the antioxidant activity of NAC itself, is responsible for the diminished downstream apoptotic effects.”

“Pretreatment with NAC blocked BITC and PEITC induced ROS elevation and NFκB inhibition.”

“In this paper, we report that the NAC conjugates of four naturally occurring ITCs, including allyl ITC , benzyl ITC (BITC), phenethyl ITC and sulforaphane, potently inhibited the growth of cells derived from both low-grade superficial and high-grade invasive human bladder cancers and drug-resistant bladder cancer cells.”

“Viability loss in cells exposed to MMC was decreased by inhibitors of caspase-3, -8 and -9 and attenuated by antioxidants ( N-acetylcysteine , dithiothreitol, ascorbate and rutin).”

“Aerobically, the PZ-51 and NAC combination inhibited the toxicity of MMC at concentrations of between 0.25 and 2 μm but had no effect on PM toxicity.”

“Glutathione (1 and 5 mM) and N-acetylcysteine (1 and 10 mM) both inhibited MC alkylation of NBP in nuclear preparations from rat liver and EMT6 tumor cells by 50-60%.”