“As both the level of intracellular reactive oxygen species (… expression of genes involving DNA repair activated by MCZ were reduced when … treatment of NAC , we propose that the damage caused by accumulation of ROS under MCZ stress … major reason for the transcription and transposition activation of the Zorro2 retrotransposon.”
“Intriguingly, the transcription activity of Zorro2 retrotransposons was significantly inhibited when the cells were treated with MCZ together with antioxidant N-acetyl-L-cysteine (NAC).”