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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Methamphetamine
Research Papers that Mention the Interaction
“The use of NAC , a potent antioxidant, reversed the neurotoxic effects of HIV and methamphetamine , suggesting a novel approach to ameliorate the effects of HIV- and methamphetamine-associated cognitive deficits.”
Human Immunodeficiency Virus Type 1 and Methamphetamine-Mediated Mitochondrial Damage and Neuronal Degeneration in Human Neurons“N-acetylcysteine NAC ) has been found to reduce the craving for methamphetamine and other drugs, but its effect on methamphetamine use and other clinically related endpoints are uncertain.”
“ N-acetylcysteine also has antioxidant properties that protect against methamphetamine-induced toxicity and it may therefore assist in the management of the neuropsychiatric and neurocognitive effects of methamphetamine.”
“ N-Acetylcysteine , catalase, and l-NG-monomethyl arginine citrate inhibited the ROS/RNS fluorescence signal induced by methamphetamine , which suggests the formation of hydrogen peroxide and RNS.”
“Systemic injection of METH produced a sustained increase in NAc temperature, which was reversed by the DA D1 receptor antagonist SCH 23390 or acupuncture at HT7.”
Acupuncture inhibition of methamphetamine‐induced behaviors, dopamine release and hyperthermia in the nucleus accumbens: mediation of group II mGluR“Interestingly, systemic administration of N-acetylcysteine (NAC), a drug that both upregulates GLT-1 and promotes glial-glutamate release, reduced cued methamphetamine seeking.”
“Our observations suggest that maternal METH exposure induced differential expression patterns of neurodevelopment‐related genes in the HPC and NAc of male and female mice, which may underlie the different cognitive behavior phenotypes in both genders.”
“These results suggest that NAC could prevent the behavioral changes (acute hyperlocomotion and development of behavioral sensitization) in rats and neurotoxicity in rat striatum after administration of MAP , and that NAC would be a useful drug for treatment of several symptoms associated with MAP abuse.”
“These results suggest that NAC could attenuate the reduction of DAT in the monkey striatum after repeated administration of MAP.”
“These results suggest that NAC could attenuate the reduction of DAT in the monkey striatum after repeated administration of MAP.”
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