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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Metformin
Research Papers that Mention the Interaction
“The BMI- and insulin-lowering effects of metformin were significantly higher than NAC after long-term treatment.”
Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome.“ N-acetyl-l-cysteine enhanced the inhibitory effects of metformin on Cd-induced ROS and apoptosis.”
“Amifostine (400 mg/kg), administered 30 min prior to … in a 2.6-fold survival elevation, while metformin administered 24 h after … in combination with NAC (400 mg/kg), MESNA (300 mg/kg) or captopril (200 mg/kg) … survival by 2.6-, 2.8- and 2.4-fold, respectively.”
“A potent antioxidant, N-acetylcysteine (NAC) suppressed all pro-apoptotic changes as well as ROS generation induced by metformin.”
“Furthermore, N-acetyl-l-cysteine (NAC), a ROS scavenger, abrogated the effects of metformin on TFE3-dependent autophagy.”
“ MET was found to elevate intracellular ROS levels in a dose-dependent manner, while pretreatment with NAC attenuated these effects.”
“Of note, co-incubation with agents that block reactive oxygen species (ROS) production (e.g. N-acetylcisteine ) dramatically enhanced the ability of metformin to decrease HER2 expression.”
“On this basis, the current results support the notion that the combination of NAC and MET can shield the diabetic heart against impaired glucose utilization and therefore its long-term protective effect warrants further investigation.”
An In Vitro Study on the Combination Effect of Metformin and N-Acetyl Cysteine against Hyperglycaemia-Induced Cardiac Damage
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