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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Acetylcysteine and Metformin



Research Papers that Mention the Interaction

The BMI- and insulin-lowering effects of metformin were significantly higher than NAC after long-term treatment.
Journal of gynecology obstetrics and human reproduction  •  2017  |  View Paper
Furthermore, N-acetyl-l-cysteine (NAC), a ROS scavenger, abrogated the effects of metformin on TFE3-dependent autophagy.
Free radical research  •  2018  |  View Paper
MET was found to elevate intracellular ROS levels in a dose-dependent manner, while pretreatment with NAC attenuated these effects.
Inflammation  •  2018  |  View Paper
Of note, co-incubation with agents that block reactive oxygen species (ROS) production (e.g., N-acetylcysteine ) dramatically enhanced the ability of metformin to decrease HER2 expression.
Cell cycle  •  2009  |  View Paper
On this basis, the current results support the notion that the combination of NAC and MET can shield the diabetic heart against impaired glucose utilization and therefore its long-term protective effect warrants further investigation.
Nutrients  •  2019  |  View Paper
A potent antioxidant, N-acetylcysteine (NAC) suppressed all pro-apoptotic changes as well as ROS generation induced by metformin.
Biological & pharmaceutical bulletin  •  2019  |  View Paper
MTF+NAC=treated with N-acetyl cysteine plus metformin (the offered doses) and iv.
International journal of fertility & sterility  •  2014  |  View Paper
Amifostine (400 mg/kg), administered 30 min prior to … in a 2.6-fold survival elevation, while metformin administered 24 h after … in combination with NAC (400 mg/kg), MESNA (300 mg/kg) or captopril (200 mg/kg) … survival by 2.6-, 2.8- and 2.4-fold, respectively.
Radiation research  •  2014  |  View Paper