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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Ketamine
Research Papers that Mention the Interaction
“Whereas animal tudies have suggested that NAC is able to reverse the neurobehavoral effects of ketamine , this study in human volunteers did not emonstrate a comparable pattern.”
Translating the Rosetta Stone of N-Acetylcysteine“In the absence of N-acetylcysteine, a concentration of ketamine that produces an internal embryo exposure level comparable to human anesthetic plasma concentrations significantly reduced heart rate and body length and those effects were prevented by N-acetylcysteine co-treatment.”
“ Ketamine also reduced the areas occupied by serotonergic neurons in the brain, whereas N-acetylcysteine co-exposure counteracted this effect.”
N-acetylcysteine prevents ketamine-induced adverse effects on development, heart rate and monoaminergic neurons in zebrafish“Furthermore, dendritic spine density was increased in the NAc of both males and females administered 5 mg/kg ketamine , an effect specific to the NAc shell (NAcSh) in males but to both the NAc core (NAcC) and NAcSh in females.”
“ Ketamine also increased nitrite/nitrate in the PFC, hippocampus, amygdala, and NAc.”
“Myeloperoxidase activity increased in the hippocampus and NAc after ketamine administration.”
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