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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
supplement:
Isothiocyanate
Research Papers that Mention the Interaction
“Here we have demonstrated, using [(14)C]… ITC and [(14)C]sulforaphane, that NAC pretreatment significantly reduces ITC cellular uptake by conjugating with ITCs in the medium, suggesting that reduced uptake of ITCs, rather than the antioxidant activity of NAC itself, is responsible for the diminished downstream apoptotic effects.”
A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced reactive oxygen species-mediated apoptosis.“In this paper, we report that the NAC conjugates of four naturally occurring ITCs , including allyl ITC, benzyl ITC (BITC), phenethyl ITC and sulforaphane, potently inhibited the growth of cells derived from both low-grade superficial and high-grade invasive human bladder cancers and drug-resistant bladder cancer cells.”
“The effects of PITC were reversed by N-Acetyl-L-cysteine.”
Propyl isothiocyanate induces apoptosis in gastric cancer cells by oxidative stress via glutathione depletion
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