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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Acetylcysteine and Isosorbide Dinitrate

Research Papers that Mention the Interaction

In addition, compared with placebo, a significant difference (p < 0.05) in favor of NAC was observed regarding time to angina (507±63 … total ST segment depression (1.8±0.9 versus 3.1±0.4 mm) ConclusionsThese results suggest that infusion of high doses of NAC … ISDN for ….
In contrast, time to onset of angina, time to 1-mm ST segment depression, and total amount of ST segment depression were still significantly improved after 24-hour infusion of ISDN plus NAC (p < 0.05).
Circulation  •  1992  |  View Paper
During treatment with ISDN + NAC , time to 1-mm ST depressions was significantly prolonged (441 $$ 44 vs. 381 $$ 40 s. mean $$ SEM) and total ST segment depression significantly reduced (1.9 $$ 0.7 vs. 3.5 $$ 0.8 mm) as compared with baseline values.
NAC augmented the antiischemic effects of ISDN as assessed by ECG.
The reduction in ST segment depression was significantly more pronounced during ISDN + NAC (46%) as compare with ISDN + placebo (23%), Although exercise time and time to angina pectoris were unaffected.
Journal of cardiovascular pharmacology  •  1991  |  View Paper
In the clinical setting, co-administration of NAC and ISDN delays and partially prevents tolerance to the antianginal and antiischemic effects normally seen in patients with stable angina pectoris during treatment with ISDN.
Danish medical bulletin  •  1995  |  View Paper