Possible Interaction: Acetylcysteine and Isoproterenol

“It is concluded that the addition of isoproterenol to an acetylcysteine aerosol in the above ratio can eliminate the ventilatory impairment induced by the latter and is therefore indicated for those patients with chronic obstructive lung disease who benefit from a mucolytic agent.”

“The protection was maximum with the use of NAC before the ISP injection and continued after the injection for 12 days.”

“ NAC also attenuated the blunted inotropic response to ISO and Ca(2+) (P < 0.01, for each).”

“The free radical scavenger NAC caused a significant attenuation of cardioprotection induced by isoproterenol when administered during both trigger and mediation phases, while being effective during the trigger phase with denopamine and during reperfusion in formoterol preconditioned hearts.”

“ NAC inhibits the pro-inflammatory factors expressions (TNF-αand IL-1β) stimulated by ISO.”

“The myocardial injury induced by ISO was significantly reduced by the treatment of NAC as judged by the reduction of myocardial necrosis.”

“Conclusion These results suggest that NAC and melatonin decreased the MAP and heart rate and improved the chronotropic response to isoproterenol in SHRs, in association with an inhibition of sympathetic activity and the restoration of cardiac β-adrenoceptor function.”

“Combining isoproterenol and NAC increased the GSH/GSSG ratio by an additional 36%.”

“The antioxidant NAC alone did not increase cardiac power (mJ/min/g wet: 11 +/- 1 in untreated and 15 +/- 2 in NAC treated stunned hearts), but NAC potentiated the increase in power produced by 2 n M isoproterenol (isoproterenol alone: 50+/-10; NAC plus isoproterenol: 133 +/- 24).”