Possible Interaction: Acetylcysteine and Isoniazid

“Our results revealed that by virtue of immune modulation, the addition of NAC to subprime levels of isoniazid (INH) and rifampicin (RIF) was indeed capable of inducing complete clearance of M. tb among healthy individuals.”

“Our results indicate that there was not only an increase in beneficial immunomodulatory effects but also a greater reduction in the intracellular viability of M. tuberculosis when macrophages were treated with the combination of antibiotics INH , RIF, EMB, or PZA) and NAC.”

“In infected murine macrophages, the addition of N-acetylcysteine to isoniazid treatment potentiated the killing of Mtb.”

“Taurine (200 μmol L-1) and N-acetylcysteine (200 μmol L-1) effectively countered the toxic effects of isoniazid and/or hydrazine by decreasing ROS formation, lipid peroxidation, and mitochondrial damage.”

“Supplementation of NAC with INH protected the animals against hepatotoxic reactions by minimizing the free radical induced tissue injury and overall maintenance of the endogenous scavengers of free radicals.”

“The effect of prodrug of INH with NAC in restoring the levels of the enzymes superoxide dismutase and glutathione peroxidase and abrogating liver damage was noteworthy especially.”

“ INH caused a significant reduction of nearly 40% in cell recovery compared with control (P < 0.0001), although the co-incubation with either glutathione (GSH, 1mM) or ( NAC , 1mM) showed abolition of INH toxicity.”

“In contrast, the addition of GSH or NAC 1h after INH failed to protect the cells from INH toxicity (P < 0.0001).”

“In comparison with the effect of selected … cells alone, the presence of either N-acetyl cysteine (NAC) or glutathione caused … in the toxicity of INH , as well as on the 4-benzyloxy derivative, although both increased the … 4-N,N-dimethylamino-1-naphthylidene and a 2-t-butylthio derivative.”