Possible Interaction: Acetylcysteine and Iron, Dietary

“Addition of NAC to drinking water protected KO + Fe from hepatic steatosis, injury and fibrosis, and prevented activation of AKT, ERK, NF-κB and reappearance of β-catenin.”

“The reactivation of latent HIV-1 by iron or heme arginate was inhibited by antioxidant N-acetyl cysteine , or by an iron chelator desferrioxamine, suggesting that the effects were mediated by iron- or heme-induced redox stress.”

“Preincubation with the antioxidant N-acetyl-l-cysteine (NAC) resulted in increased DMT1 at the apical membrane before and after addition of iron.”

“Furthermore, NAC (but not CP) adversely affected the integrity of Fe and Zn plasma metalloproteins in a dose and a time dependent manner.”

“This effect of Gbe was diminished yet not totally abolished when FeCl3 was added to the medium of incubation, whereas N-acetylcysteine even slightly enhanced CsA stimulated lipid peroxidation in the presence of iron.”

“The antioxidant N-acetycysteine can turn into a prooxidant molecule in presence of iron ions.”

“Under these …-term Fe administration exerted significant protection against IR liver injury, as shown by 85% and 60% decreases in IR-induced serum AST and … (P < 0.05), respectively, and normalization of hepatic histology, glutathione levels, and NF-κB activation, changes that were suppressed by NAC administration prior … Fe.”

“ NAC would reduce the mortality of rats after acute, toxic oral doses of iron.”

“The administration of NAC probably increased the absorption of iron through the gastrointestinal tract, causing higher serum iron levels with significant hepatic damage.”

“Posttreatment with NAC abrogated these changes induced by FE.”

“Posttreatment with NAC was effective to alleviate the pathologic and biochemical changes caused by FE.”