Possible Interaction: Acetylcysteine and Interleukin-10

“Furthermore, NAC decreases TNF-α, IL-1β, IL-6, IL-8, IL-10 , and IL-17 serum levels in patients with sepsis, severe burns, acute liver failure, or peritoneal dialysis and may also reduce cytokine storm in COVID-19.”

“When studying the effect of NAC on T‐cell‐mediated immunity in vitro, we found that moderate levels of NAC (0.4–3.2 mM) increased alloantigen‐induced proliferation, expression of activation markers CD25 and CD71 on T cells, and production of IFN‐γ and IL‐10.”

“ N-acetyl-cysteine treatment decreased the levels of IL-10 , IL-6, TNF-alpha and IL-1, in blood cultures derived from tuberculosis patients, favoring the host immune cells to successfully control M. tuberculosis replication.”

“ NAC also enhanced LPS-induced IL-10 secretion, while AMB did not.”

“ NAC and DFMO suppressed NO and interleukin 10 (IL-10) production by splenocytes, while DFMO increased the levels of IL-12.”

“Administration of NAC attenuated those CS-induced adverse effects in the mice and increased anti-inflammatory factor IL-10 levels in BAL fluids significantly (all p < 0.05).”

“Results: NAC and NAC + OT significantly decreased MDA and TNF-α levels and increased IL-10 levels and GPx activities.”

“ NAC was effectively significant in preventing TGF-&bgr; and IL-6 expression and further augmented the IL-10 expression.”

“In all groups, NAC decreased the synthesis of interferon-γ and nitric oxide, while increasing the levels of interleukin-10 , but it did not influence the production of interleukin-4.”

“ NAC pretreatment attenuated the increases in TNF-α and IL-6 levels, but augmented IL-10 levels at 2 h post-LPS.”