Possible Interaction: Acetylcysteine and Interferons

“The difference between the results in patients treated with interferon and N-acetyl cysteine and those on interferon alone was significant.”

“Amongst patients receiving IFN plus NAC , sustained virological responses were observed in 5.5%, transient responses in 26% and non‐response in 68.5%.”

“Interestingly, we discovered that NAC significantly reduced DENV production in HepG2 cells and in liver of DENV‐infected mice by induction of antiviral responses via interferon signaling.”

“Taken together, the data obtained demonstrate that the addition of NAC has positive effects on the elongation of the culture period, improving the production and increasing the sialylation of IFN‐β in NaBu‐treated CHO cells.”

“IFN-γ treatment increased the accumulation of intracellular ROS in melanocytes, while ROS scavenger N-acetyl cysteine (NAC) effectively inhibited IFN-γ induced p21 expression and melanocyte senescence.”

“IL-6 and HSP-70 release was significantly induced by IFN-γ treatment, which was largely inhibited by NAC.”

“In contrast, NAC up‐regulated interferon‐γ ( IFN‐γ ) production.”

“In conclusion, NAC enhances the response to IFN in CHC.”

“Supplementation of IFN with NAC induced a near normalization of intralymphocytic glutathione, but plasma levels were only moderately increased.”

“In all groups, NAC decreased the synthesis of interferon-γ and nitric oxide, while increasing the levels of interleukin-10, but it did not influence the production of interleukin-4.”