Possible Interaction: Acetylcysteine and Interferon-Alpha

“ NAC also reduced -H2AX foci formation in human lymphoblastoid cells but had no protective effect in the colony survival assay.”

“Although NAC treatment increased the IκBα phosphorylation, it failed to increase TNF-α levels … signaling 1, which specifically prevented nuclear translocation of p65 NF-κB. We demonstrate that NAC at 3 …–induced IFN-γ production by PBMCs from patients with active tuberculosis … immune response toward the protective Th1 type.”

“ NAC also reduced gamma-H2AX foci formation in human lymphoblastoid cells but had no protective effect in the colony survival assay.”

“ N-acetyl-l-cysteine reduced proliferation and IFNγ in GO, and HA and IL1β in both GO and control fibroblasts.”

“When studying the effect of NAC on T‐cell‐mediated immunity in vitro, we found that moderate levels of NAC (0.4–3.2 mM) increased alloantigen‐induced proliferation, expression of activation markers CD25 and CD71 on T cells, and production of IFN‐γ and IL‐10.”

“We have previously reported that pretreatment of human lymphoblastoid cells with the hydroxyl radical scavenger, N-acetyl cysteine , attenuates doxorubicin-induced DNA damage signalling through the ATM protein kinase.”

“In vitro, NAC pre-treatment significantly reduced TNF-α and NF-κB, TNF-α, IFN-γ , and IL-6 expression in LPS-induced IPEC-J2 cells.”

“This inhibitory effect of IFN‐γ on iTreg generation was significantly abrogated after N‐acetyl‐L‐cysteine treatment both in vitro and in vivo, indicating that IFN‐γ regulation of iTreg generation is dependent on ROS‐mediated apoptosis.”

“Augmenting intracellular soluble thiol pools (∼2-fold) with 15 mM NAC blocked induction of IFN-γ and increased production of IL-4 without causing significant changes in intracellular glutathione levels.”

“ N-Acetylcysteine or glutathione could also completely revert the mycobacteriostatic effects of PA or PA plus IFN-γ.”