Possible Interaction: Acetylcysteine and Insulin

“In addition, in alveolar epithelial cells, insulin increased the expression levels of α‑, β‑ and γ‑ENaC , as well as the level of phosphorylated SGK1, which were then inhibited by the selective targeting of PI3K or SGK1 by siRNA.”

“Our previous study reported that insulin increased the expression of α‑ENaC , possibly via the serum/glucocorticoid‑inducible kinase‑1 (SGK1) pathway in ALI; however, the upstream regulator of SGK1 activity remains unclear.”

“Moreover, NAC can modulate certain signaling pathways in both insulin target cells and β cells.”

“The antioxidant agents, including catalase and N-acetyl-l-cysteine , could inhibit cardiomyocyte hypertrophy induced by insulin , suggesting that ROS is necessary for insulin to induce hypertrophy.”

“ Insulin sensitivity was reduced (-5.9%, P < 0.05) by NAC compared with CON without decreased phosphorylation of Akt or AS160.”

“It increased ROS production; pretreatment with N-acetyl-L-cysteine (NAC), a ROS scavenger, reversed HUA-inhibited glucose uptake induced by insulin.”

“p38 MAPK inhibitor, SB203580, as well as NAC , could inhibit the VSMC proliferation induced by co-incubation of GSA and insulin.”

“Therefore, chronic treatment with N-acetylcysteine increases insulin sensitivity and prevents the blood pressure increase associated with fructose feeding in rats, the mechanism may involve the decrease of oxidative stress and alpha-adrenoceptor-mediated vasoconstriction.”

“In cell-free media, the 2 reductants, dihydrolipoate and N-acetylcysteine , rapidly decreased immunoreactive insulin , but alpha-lipoate was ineffective.”

“Investigation of this phenomenon revealed that 1) depletion of GSH with … and normalized by NAC, 3) exposure to high glucose and insulin … NAC , 4) EPR (electron paramagnetic resonance) spectroscopy showed a decreased amount of vanadyl (+4) … of recombinant PTP1Bin vitro was more sensitive to vanadate (+5) than vanadyl (+4).”

“In the STR, increased dopamine release was observed in the groups treated with 200 and 400 mU insulin, whereas a suppression of a dopamine … peripheral insulin injection causes dopamine metabolism to change in both the NAC and STR, and at least in part support the hypothesis that insulin … NAC ….”