Possible Interaction: Acetylcysteine and Ifosfamide

“We have shown that n-acetylcysteine (NAC) successfully mitigates nephrotoxicity of ifosfamide in cell and rodent models.”

“These observations suggest that NAC may improve the risk/benefit ratio of ifosfamide by decreasing ifosfamide-induced nephrotoxicity without interfering with its antitumor effect in cancer cells clinically treated with ifosfamide.”

“ Ifosfamide dosage was reduced solely for urothelial toxicity in 11 patients receiving NAC compared with none of the patients receiving mesna (p<0.0001).”

“ N-Acetyl-l-cysteine can confer protection against nitrosative and … in renal tissue induced by holoxan by suppressing NADPH oxidase activation, malondialdehyde, nitric oxide and restoring SOD activity which led to the reduction … reactive oxygen species production and subsequently might effectively improve the gonadal hormone disturbance and reproductive functions.”

“Whereas administration of N-acetyl-l-cysteine prior to treatment with holoxan and then concurrently with it modulated significantly fertility index, progesterone level, decreasing postimplantation loss, resorbed fetuses and improved fetal growth.”

“Both ALA and NAC markedly reduced the severity of renal dysfunction induced by IFO.”

“A significant 60% decrease in cellular viability occurred when cells were treated daily with BSO and IF for 96 h. This decrease was significantly reduced when cells were concurrently treated with NAC in a concentration-dependent manner.”

“Supplementation with NAC may reduce or prevent the degree of cellular cytotoxicity induced by IF.”