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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Hypochlorite
Research Papers that Mention the Interaction
“Both hypochlorous acid production and endothelial lysis were abrogated by N-acetylcysteine (NAC), an antioxidant molecule.”
Natural and disease associated anti-myeloperoxidase (MPO) autoantibodies.“The in vitro exposure of human red blood cells to NAC increased the cellular low‐molecular‐weight thiol levels and retarded tert‐butylhydroperoxide‐induced cellular thiol depletion and membrane lipid peroxidation as well as effectively inhibited hypochlorous acid‐induced erythrocyte lysis.”
“As HOCl has been shown to react with thiol-containing compounds like glutathione and N-acetylcysteine protecting LDL from HOCl modification, we have tested the ability of hydrogen sulfide (H2S)—which has recently been identified as an endogenous vasorelaxant—to counteract the action of HOCl on LDL.”
“Both HOCl production and endothelial lysis were abrogated by N-acetylcysteine (NAC), an antioxidant molecule (P < 0.05 and P < 0.0001, respectively).”
“The effects of HOCl could be blocked by coadministration of antioxidants, i.e., N-acetylcystein (NAC), uric acid (UA) and ascorbic acid (AA).”
Vulnerability of brain tissue to inflammatory oxidant, hypochlorous acid“The effects of HOCl on the isolated organ and the enzyme preparation could be precluded with thiol group-containing compounds such as reduced glutathione and N-acetylcysteine.”
“These effects of HOCl were significantly reduced by pretreatment of l -arginine (10(-3)m), sodium nitroprusside (SNP, 10(-5) m) and N -acetyl-l-cysteine ( NAC, 10(-4) m).”
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