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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Hydroquinone
Research Papers that Mention the Interaction
“However, N-acetylcysteine did significantly reduce the cytotoxicity of hydroquinone.”
Anticancer activity of botanical alkyl hydroquinones attributed to topoisomerase II poisoning.“The presence of N-acetyl-L-cysteine also prevented hydroquinone inhibiting hemin-induced hemoglobin synthesis and mRNA expression of γ-globin in K562 cells.”
“ Hydroquinone caused reactivation of a methylated reporter plasmid that was prevented by the addition of N-acetylcysteine.”
“Popular antioxidants such as N-acetyl-L-cysteine and cysteine also reduced the radical intensity and cytotoxic activity of HQ.”
“ N-acetyl cysteine also blocks nearly completely the dopamine induced increase in reactive oxygen species production and the formation of quinoprotein adducts in mitochondrial fraction within PC12 cells and also the accumulation of quinone products in the culture medium.”
Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: Implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease.“In contrast, additions to hepatocytes of 5 mM of dithiothreitol, cysteine, N-acetyl-L-cysteine or ascorbic acid significantly inhibited the cytotoxicity induced by 0.5 mM PHQ ; GSH, protein thiols and ATP losses were also prevented.”
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