Possible Interaction: Acetylcysteine and Hydrogen Peroxide

“Further characterisation of plasma using a … addition of a sub-threshold of hydrogen peroxide to post-exercise (and not pre-exercise) plasma caused a sixfold increase in the radical oxygen … ± 131 to 3607 ± 488 change in fluorescent intensity [ΔFI]), which was inhibited using 60 mM N-acetyl-l-cysteine (…).”

“… NAC group exhaled 2.3-fold (0.17+/-0.33 microM vs. 041+/-0.26 microM, P<0.04) [median 0.01 microM, quartile range (….40+/-0.25 microN, P<0.05) median = 0.00 microM, qr = 0.23 vs. median = 0.36 microM, qr = 0.51] less H2O2 ….”

“The concentration of authentic plasma hydroperoxide was significantly reduced by the administration of NAC which suggests diminished oxidative stress during acute myocardial infarction.”

“Mutants desD399Y and desR406W had delayed oxidation kinetics following H2O2 stress prevented by N-acetyl-l-cysteine pretreatment.”

“ H2O2 treatment directly enhanced AS cell growth and migration, which was counteracted by antioxidant N-acetyl cysteine (NAC).”

“Treatment with N‐acetyl‐L‐cysteine decreased the protein level of cofilin while treatment with H2O2 increased it, further confirming the role of ROS in regulating cofilin degradation.”

“In TCMK-1 cells, Klotho and NAC attenuated the elevation in RIP1, RIP3, and LDH release induced by H/R or H2O2.”

“Furthermore, NAC also prevents phosphorylation of JNK and p53 induced by H2O2.”

“On the other hand, quenching of H2O2 by antioxidants, resveratrol (RSV), or N-acetylcysteine (NAC) effectively blocked TRPM2-mediated Ca2+ influx, decreased intracellular Ca2+ overload, and increased cell survival.”

“SIM, APO, and NAC either partially inhibit or completely block the TNF-α induced H2O2 or superoxide production.”