Possible Interaction: Acetylcysteine and Homocysteine

“Under control conditions, a hemodialysis session reduced plasma homocysteine concentration to 58±22% predialysis (mean±SD), whereas in the presence of acetylcysteine , the plasma homocysteine concentration was significantly more reduced to 12±7% predialysis (P <0.01).”

“In addition, supplementation with NAC seems to be able to partially prevent excessive increases in the levels of homocysteine in plasma and of oxidized homocysteine in whole blood, and might thereby contribute to the prevention of oxidative stress.”

“Acute administration of N-acetylcysteine (NAC) may induce alterations in plasma and urinary levels of homocysteine (Hcy) and cysteine (Cys).”

“BACKGROUND N-acetylcysteine is a novel antioxidant that has been reported to reduce plasma homocysteine concentrations and improve endothelial function.”

“It was hypothesized that N-acetylcysteine would reduce plasma homocysteine concentrations and improve brachial endothelial function in cardiac transplant recipients.”

“It has been suggested that N-acetylcysteine NAC ) breaks disulphide bonds in Lp(a) as well as between homocysteine and plasma proteins.”

“ NAC significantly decreased malondialdehyde (MDA) (SMD = -1.44 μmol/L; 95% CI: -2.05, -0.84; P < 0.…-8 (WMD = -2.56 pg/ml; 95% CI: -3.89, -1.23; P < 0.001) and homocysteine (WMD = -1.45 pg/ml; 95% CI: -….74, -0.17; P = 0.027) levels.”

“In contrast, Hcy levels significantly decreased or showed a strong tendency toward lower values depending on the NAC dose.”

“CONCLUSIONS Four weeks of oral NA tr eatment significantly decreased plasma tHc y co ncentrations, irrespective of lipid or smoking status, and lowered systolic blood pressure in both normolipidemic and hyperlipidemic men, with significant diastolic blood pressure reductions in the HYL group only.”

“ N-acetylcysteine (NAC), a thiol-containing antioxidant, acutely lowers tHcy and possibly also blood pressure.”

“The HYL group had total … >150 mg/dL. RESULTS NAC treatment significantly (P = 0.001, multivariate …) lowered postabsorptive plasma concentrations of tHcy by -11.7% ± 3.0% (placebo: 4.1% ± 3.6%) while increasing those of …% (placebo: 4.0% ± 3.4%) with no significant impact of hyperlipidemia or smoking.”

“ N-acetylcysteine therapy could induce an additional decrease in homocysteine removal during dialysis, thus representing an alternative approach in the attempt to lower cardiovascular risk in these patients.”

“On the contrary, omega-3 fatty acids and some nutraceuticals, such as N-acetyl cysteine , taurine, or S-adenosyl-methionine, reduce both Hcy serum concentration and cardiovascular risk.”