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Last Updated: 4 months ago

Possible Interaction: Acetylcysteine and Homocysteine





Research Papers that Mention the Interaction

Under control conditions, a hemodialysis session reduced plasma homocysteine concentration to 58+/-22% predialysis (mean+/-SD), whereas in the presence of acetylcysteine , the plasma homocysteine concentration was significantly more reduced to 12+/-7% predialysis (P<0.01).
Circulation  •  2004  |  View Paper
In addition, supplementation with NAC seems to be able to partially prevent excessive increases in the levels of homocysteine in plasma and of oxidized homocysteine in whole blood, and might thereby contribute to the prevention of oxidative stress.
Clinical science  •  2003  |  View Paper
Acute administration of N-acetylcysteine (NAC) may induce alterations in plasma and urinary levels of homocysteine (Hcy) and cysteine (Cys).
Pharmacology  •  2003  |  View Paper
BACKGROUND N-acetylcysteine is a novel antioxidant that has been reported to reduce plasma homocysteine concentrations and improve endothelial function.
It was hypothesized that N-acetylcysteine would reduce plasma homocysteine concentrations and improve brachial endothelial function in cardiac transplant recipients.
The Canadian journal of cardiology  •  2002  |  View Paper
We examined whether predialysis administration of oral N-acetylcysteine (NAC), which acutely increases the non-protein bound, dialyzable fraction of plasma homocysteine , might augment the homocysteine-lowering effect of dialysis therapy.
Atherosclerosis  •  1996  |  View Paper
It has been suggested that N-acetylcysteine NAC ) breaks disulphide bonds in Lp(a) as well as between homocysteine and plasma proteins.
Plasma thiols were significantly reduced during treatment with NAC: homocysteine by 45% (P < 0.0001), cysteinyl glycine by 24% (P < 0.0001) and cysteine by 11% (P = 0.0002).
Atherosclerosis  •  1996  |  View Paper
Serum lipid peroxidation, luteinizing hormone, testosterone, insulin, interleukin-1 beta, and homocysteine levels were decreased by NAC treatment although serum vitamin A, beta-carotene, vitamin E, and total antioxidant status were increased by the NAC treatment.
Free radical research  •  2015  |  View Paper
CONCLUSIONS Four weeks of oral NAC treatment significantly decreased plasma tHcy concentrations, irrespective of lipid or smoking status, and lowered systolic blood pressure in both normolipidemic and hyperlipidemic men, with significant diastolic blood pressure reductions in the HYL group only.
N-acetylcysteine (NAC), a thiol-containing antioxidant, acutely lowers tHcy and possibly also blood pressure.
The HYL group had total … >150 mg/dL. RESULTS NAC treatment significantly (P = 0.001, multivariate …) lowered postabsorptive plasma concentrations of tHcy by -11.7% ± 3.0% (placebo: 4.1% ± 3.6%) while increasing those of …% (placebo: 4.0% ± 3.4%) with no significant impact of hyperlipidemia or smoking.
The American journal of clinical nutrition  •  2015  |  View Paper
CONCLUSIONS NAC therapy induces a significant additional decrease in homocysteine removal during dialysis.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation  •  2012  |  View Paper
NAC administration resulted in a significant reduction in total homocysteine plasma concentrations in ESRD and healthy subjects, but had no effect on several other oxidative stress markers.
Clinical journal of the American Society of Nephrology : CJASN  •  2010  |  View Paper
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