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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Acetylcysteine
drug:
Hemin
Research Papers that Mention the Interaction
“ NAC inhibited the intracellular accumulation of hemin and prevented hemin-induced cell growth inhibition, cell death, oxidative stress, and accumulation of ubiquitinated proteins.”
Formation of novel N-acetylcysteine-hemin adducts abrogates hemin-induced cytotoxicity and suppresses the NRF2-driven stress response in human pro-erythroid K562 cells.“EDTA, N‐acetylcystein and glutathione prevented the toxicity of hemin and hemin/MAA.”
“Both NAC and AA eliminated transient increased ROS levels after hemin treatment, inhibited hemin-induced hemoglobin synthesis, and decreased mRNA expression levels of β-globin, γ-globin, and GATA-1 genes significantly.”
“Albumin decreased and N-acetylcysteine (NAC) both prevented and reversed rigidity induced by hemin.”
“ Hemin induced significant increase in reactive oxygen species (ROS) production and hemin‐induced angiogenic response of EPCs was substantially reduced by treatment with N‐acetylcysteine.”
Hemin promotes proliferation and differentiation of endothelial progenitor cells via activation of AKT and ERK“The anti‐tumour effect of haemin and IL‐2 was enhanced (63% decrease in metastases) by administration of the thiol compound, N‐acetylcysteine.”
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