Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Acetylcysteine and Glutathione





Research Papers that Mention the Interaction

N-acetylcysteine resulted in … significant GSH increase to 1·93 ± 0.23 mM within 12-30 min after completion of infusion ( n = 21, p < 0.0001, paired t-… those who did not receive N-acetylcysteine ( n = 3, GSH = 1.66 ± 0.06 mM and 1.64 ± 0.09 mM).
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism  •  2018  |  View Paper
N-acetyl cysteine NAC ) increases brain glutathione in rodents.
Biological Psychiatry  •  2008  |  View Paper
Four treatment groups were analyzed; NAC at a dose of 2,400 mg per day decreased the percent dense cells from 20.1 +/- 2.9 to 12.6 +/- 2.1 (P < 0.05) and increased red cell glutathione levels from 292.8 +/- 74.5 to 576.7 +/-
Four treatment groups … analyzed; NAC at a dose of 2,400 mg per day decreased the percent dense cells from ….1 +/- 2.9 to 12.6 +/- 2.1 (P < 0.05) and increased red cell glutathione levels from 292.8 +/- 74.5 to ….7 +/- 155.1 (P < 0.05).
American journal of hematology  •  2003  |  View Paper
Exercise decreased the reduced glutathione (P < 0.005) and increased oxidized glutathione concentrations (P < 0.005); NAC attenuated both effects (P < 0.05).
Journal of applied physiology  •  2003  |  View Paper
The increases in the GSH concentration and synthesis rate were approximately 150% and 510% greater, respectively, in the NAC group than in the control group.
The American journal of clinical nutrition  •  2002  |  View Paper
In conclusion, high-dose N-acetylcysteine supplementation increases intracellular glutathione levels slightly.
The European respiratory journal  •  2002  |  View Paper
In conclusion, the administration of high doses of NAC added to GSH significantly decreased the peroxidative stress of patients with septic shock.
American journal of respiratory and critical care medicine  •  2000  |  View Paper
Granulocyte GSH was significantly higher on days 1 and 3 when NAC was received by the patient.
NAC could act in part by replenishing the intracellular stores of glutathione (GSH) in activated granulocytes, leading to detoxification of oxygen radicals produced by these cells.
Chest  •  1996  |  View Paper
NAC also led to a 23% increase in GSH levels in the medial prefrontal cortex (GSHmPFC) as measured by 1H magnetic resonance spectroscopy.
Translational Psychiatry  •  2018  |  View Paper
Here we compare the ability of N-acetylcysteine (NAC), 2-oxothiazolidine-4-carboxylic acid (OTC), glutathione ethyl ester (GSH-EE) and N-acetylcysteine ethyl ester (NACET) to increase the intracellular concentration of GSH using primary human umbilical vein endothelial cells (HUVEC) as in vitro model.
Our experiments highlighted that NACET is largely the most efficient molecule in increasing the intracellular levels of GSH , cysteine, and γ-glutamylcysteine.
Free radical biology & medicine  •  2018  |  View Paper
Show More