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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
supplement:
Glutathione
Research Papers that Mention the Interaction
“Upon initiation of therapy, we found that the group of patients undertaking NAC exhibited significant increase in GSH levels and in total antioxidant status while displaying substantial reduction in lipid peroxidation compared to the control group.”
Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIV-Associated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial“ N-acetylcysteine resulted in … significant GSH increase to 1·93 ± 0.23 mM within 12–30 min after completion of infusion (n = 21, p < 0.0001, paired t-… those who did not receive N-acetylcysteine (n = 3, GSH = 1.66 ± 0.06 mM and 1.64 ± 0.09 mM).”
“N-acetyl cysteine NAC ) increases brain glutathione in rodents.”
“Exercise decreased the reduced glutathione (P < 0.005) and increased oxidized glutathione concentrations (P < 0.005); NAC attenuated both effects (P < 0.05).”
“The increases in the GSH concentration and synthesis rate were approximately 150% and 510% greater, respectively, in the NAC group than in the control group.”
“However, NAC significantly reduced the rise in & agr;-glutathione S-transferase after reperfusion of the donor liver.”
“ NAC attenuated the increase in & agr;-glutathione S-transferase and circulating ICAM-1 and VCAM-1 after reperfusion of the donor liver, indicating possible cytoprotective effects of NAC.”
“In conclusion, the administration of high doses of NAC added to GSH significantly decreased the peroxidative stress of patients with septic shock.”
“Treatment with N-acetyl-L-cysteine decreased plasma VCAM-1 (p = 0.01) and intraerythrocytic GSSG (p = 0.006) but increased GSH concentrations (p = 0.04) and the GSH:GSSG ratio (p = 0.004) in non-insulin dependent diabetic patients.”
“Granulocyte GSH was significantly higher on days 1 and 3 when NAC was received by the patient.”
“ NAC could act in part by replenishing the intracellular stores of glutathione (GSH) in activated granulocytes, leading to detoxification of oxygen radicals produced by these cells.”
“N‐acetylcysteïne NAC ) increases glutathione levels and is known to prevent pathology elicited by radicals and reactive species.”
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