Possible Interaction: Acetylcysteine and Glutathione Disulfide

“Exercise decreased the reduced glutathione (P < 0.005) and increased oxidized glutathione concentrations (P < 0.005); NAC attenuated both effects (P < 0.05).”

“In vitro, NAC induced a significant increase in oxidized glutathione (GSSG) reductase activity in rat liver preparations and counteracted the mutagenicity of direct-acting compounds (such as epichlorohydrin, hydrogen peroxide, 4-nitroquinoline-N-oxide and dichromate), as a result of its reducing and scavenging properties.”

“A burst of oxidized/reduced glutathione ratio was observed 3 hours after procedure that was diminished by NAC administration.”

“The oxidative glutathione disulfide GSSG ) level increased in the NAC group, however only at a trend level of significance (p = 0.09).”

“Although NAC increased the plasma ratio of reduced to oxidized glutathione , there were no differences between experimental sessions for walking tolerance and postocclusive reactive hyperemia.”

“However, this study addressed that administration of NAC or mito-Q in high concentrations resulted in a biphasic response by initiating an enhanced generation of both reduced glutathione and oxidized glutathione and enhanced production of reactive oxygen species, along with carbonylation and glutathionylation of the cellular proteins.”

“During repetitive submaximal efforts, NAC delayed fatigue (130% baseline) and inhibited glutathione oxidation.”

“The suppression of GSSG accumulation and prooxidant production by treatment with the thiol antioxidant, N-acetylcysteine , also suppressed all the increases in kinase activation and gene expression observed during glucose deprivation.”

“Treatment with NAC significantly increased jejunal superoxide dismutase activity, reduced glutathione: oxidized glutathione ratio , and the mRNA abundance of nuclear respiratory factor 2, heme oxygenase 1, and superoxide dismutase 2 in the IUGR-NAC piglets compared with the IUGR-CON piglets.”

“ NAC pretreatment reversed the abundance changes of high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein, glutamate, glutamine, oxidized glutathione , choline, phosphocholine, glycerophosphocholine, trimethylamine, and trimethylamine-N-oxide induced by Gd-DTPA.”