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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Acetylcysteine and Glutathione Disulfide

Research Papers that Mention the Interaction

Exercise decreased the reduced glutathione (P < 0.005) and increased oxidized glutathione concentrations (P < 0.005); NAC attenuated both effects (P < 0.05).
Journal of applied physiology  •  2003  |  View Paper
In vitro, NAC induced a significant increase in oxidized glutathione (GSSG) reductase activity in rat liver preparations and counteracted the mutagenicity of direct-acting compounds (such as epichlorohydrin, hydrogen peroxide, 4-nitroquinoline-N-oxide and dichromate), as a result of its reducing and scavenging properties.
Respiration; international review of thoracic diseases  •  1986  |  View Paper
A burst of oxidized/reduced glutathione ratio was observed 3 hours after procedure that was diminished by NAC administration.
Antioxidants & redox signaling  •  2018  |  View Paper
The oxidative glutathione disulfide GSSG ) level increased in the NAC group, however only at a trend level of significance (p = 0.09).
Molecular Autism  •  2016  |  View Paper
Although NAC increased the plasma ratio of reduced to oxidized glutathione , there were no differences between experimental sessions for walking tolerance and postocclusive reactive hyperemia.
American journal of physiology. Heart and circulatory physiology  •  2015  |  View Paper
However, this study addressed that administration of NAC or mito-Q in high concentrations resulted in a biphasic response by initiating an enhanced generation of both reduced glutathione and oxidized glutathione and enhanced production of reactive oxygen species, along with carbonylation and glutathionylation of the cellular proteins.
The Journal of Immunology  •  2007  |  View Paper
During repetitive submaximal efforts, NAC delayed fatigue (130% baseline) and inhibited glutathione oxidation.
Muscle & nerve  •  2005  |  View Paper
The suppression of GSSG accumulation and prooxidant production by treatment with the thiol antioxidant, N-acetylcysteine , also suppressed all the increases in kinase activation and gene expression observed during glucose deprivation.
Free radical biology & medicine  •  1999  |  View Paper
Treatment with NAC significantly increased jejunal superoxide dismutase activity, reduced glutathione: oxidized glutathione ratio , and the mRNA abundance of nuclear respiratory factor 2, heme oxygenase 1, and superoxide dismutase 2 in the IUGR-NAC piglets compared with the IUGR-CON piglets.
European Journal of Nutrition  •  2018  |  View Paper
NAC pretreatment reversed the abundance changes of high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein, glutamate, glutamine, oxidized glutathione , choline, phosphocholine, glycerophosphocholine, trimethylamine, and trimethylamine-N-oxide induced by Gd-DTPA.
Omics : a journal of integrative biology  •  2017  |  View Paper
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