Possible Interaction: Acetylcysteine and Glucose

“Solutions of L-cysteine (Cys) and N-acetyl-L-cysteine (AcCys), containing glucose or rhamnose, with or without … to pH 3, 5, and 7 and incubated at 70 degrees C for 48 h. Cys and AcCys inhibited the formation …)furfural (HMF) from glucose and methylfurfural (MF) … under acidic conditions.”

“In vitro experiments showed that high glucose induced the accumulation of reactive oxygen species and activated NLRP3 inflammasomes, which was significantly suppressed by treatment with metformin or antioxidant N-acetyl-L-cysteine.”

“If the subjects experienced hypoglycemia despite receiving N-acetylcysteine diluted in dextrose 5%, it would mean that glucose concentration would indeed be correlated to hepatic failure.”

“Thus, the results that 8.6% of subjects had hypoglycemia despite treatment with N-acetylcysteine diluted in dextrose 5% carries a different meaning than if diluted in half-normal saline.”

“Both TLR9 deficiency and the antioxidant N‐acetyl‐L‐cysteine treatment improved altered intra‐ and extracellular TSP‐1 levels under high glucose condition.”

“Treatment of ob/ob mice with N-acetylcysteine (NAC) in vivo or addition of NAC in vitro to HG-treated smooth muscle reversed the effect of glucose on the expression of miR-133a and RhoA, Rho kinase activity and muscle contraction.”

“The ROS scavenger N-acetyl-L-cysteine increased the intracellular calcium response to glucose that was associated with a small decrease in ROS content.”

“The frequency of heart malformations decreased from 82% to 27% when 2 mM N-acetylcysteine was added to the injected D-glucose.”

“Overnight exposure to hydrogen peroxide mimicked the effects of 30 mmol/l glucose on haeme-… and c-Myc mRNA levels without activating NFkappaB. On the other hand, the antioxidant N-acetyl-L-cysteine inhibited the stimulation of haeme-oxygenase 1 …-Myc expression by 30 mmol/l glucose and/… peroxide.”

“These effects of glucose were blocked by antioxidants, vitamin E, N-acetylcystein , or taurine.”

“In VIC cultures treated with glucose in combination with reactive oxygen species (ROS) inhibitor ( N-acetyl-l-cysteine ), the expression of NF-κB and BMP-2 was significantly suppressed.”