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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Gemcitabine
Research Papers that Mention the Interaction
“However, combination treatment with NAC and gemcitabine decreased tumor growth by approximately 50%.”
“In this study, we documented the molecular sites of S-glutathionylation of p65, and we investigated whether NAC can suppress NFκB signaling and augment a therapeutic response to gemcitabine in vivo.”
“ NAC treatment also markedly enhanced tumor apoptosis in gemcitabine-treated mice.”
“Together, these results indicate that adjunct therapy with NAC prevents NFκB activation and improves gemcitabine chemotherapeutic efficacy.”
N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway.
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