Possible Interaction: Acetylcysteine and Ethanol

“The antioxidants N-acetyl cysteine and vitamin C lowered the alcohol elevation of ROS and blunted the alcohol induction of CYP2A5, but not CYP2E1, suggesting ROS play a novel role in the crosstalk between CYP2E1 and CYP2A5.”

“The cytotoxicity of ethanol was suppressed by an antioxidant N-acetyl cystein pretreatment.”

“In cultured human or mouse HSC, production of CTGF, α-SMA and/or collagen was increased by ethanol treatment, an effect mimicked by acetaldehyde and blocked by 4-methylpyrazole (4-MP) or N-acetylcysteine (NAC).”

“ Alcohol treatment inactivated HNF-4alpha, which was prevented by N-acetyl-cysteine or zinc.”

“We hypothesized that n-acetylcysteine would attenuate alcohol self-administration, as well as positive subjective effects of alcohol.”

“ N-acetyl-L-cysteine and cyclosporine A, blocked ethanol and acetaldehyde-induced barrier dysfunction and tight junction disruption.”

“The ethanol toxicity was also prevented by radical trapping agents such as N-acetylcysteine and N-t-butyl-α-phenylnitrone, antioxidative agents such as catalase, superoxide dismutase, thiourea, and uric acid, and inhibitors of lipid peroxidation, such as vitamin E phosphate, Trolox, and diphenylphenylenediamine.”

“Following chronic alcohol … deprivation, and subsequent alcohol re‐access , relapse drinking resulted in blood alcohol levels of 95 to … in 60 minutes, which were reduced by 60% by either N‐acetylcysteine or aspirin and by 85% by the co‐administration … (blood alcohol: 10 to 15 mg/dL; P < .001).”

“The present … shows that chronic ethanol intake was inhibited by 50% to … low doses of either the antioxidant N‐acetylcysteine (40 mg/kg/d) or the anti‐inflammatory aspirin (ASA; 15 mg/kg/d), while … dugs led to a 70% to 75% (P < .001) inhibition of chronic alcohol intake.”

“ NAC could counteract glutamatergic dysregulation underlying ethanol addiction.”

“ NAC reduced ethanol self‐administration, motivation, seeking and relapse in dependent rats.”

“Our results demonstrate that NAC decreased ethanol self‐administration, extinction responding, and relapse in ethanol‐dependent animals, and thus strongly support clinical development of NAC for alcohol use disorders.”

“We showed that in dependent rats, the low dose of NAC (25 mg/kg) reduced ethanol self‐administration and motivation to consume ethanol, evaluated in a progressive ratio paradigm.”

“Furthermore, viral-mediated rescue of ENT1 expression in the NAc of ENT1 KO mice reduced ethanol drinking, demonstrating a possible causal link between ENT1 expression and ethanol drinking in males.”