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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Acetylcysteine
drug:
Ethacrynic Acid
Research Papers that Mention the Interaction
“Also, EA decreased glutathione levels, which were inhibited by N-acetylcysteine.”
“In elucidating the DNA damage, it was determined that EA increased the production of reactive oxygen species, which was inhibited by N-acetylcysteine and deferoxamine but not by ascorbic acid and trolox.”
“ EA additionally induced a significant increase in PS1 mRNA expression, which was inhibited by NAC.”
“When the glutathione conjugate of EA was incubated with a 5-fold molar excess of N-acetyl-L-cysteine or GST P1-1, a time-dependent transfer of EA to N-acetyl-L-cysteine or GST P1-1 was observed.”
Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1.“However, we observed that when the eye was treated before ethacrynic acid-cysteine administration with topical acetylcysteine , the corneal side effects were reduced further and the intraocular pressure effect remained.”
Effects of topical ethacrynic acid adducts on intraocular pressure in rabbits and monkeys.“Furthermore, 0.4-3.2 mM ethacrynic acid , rather than 1-16 mM BSO could inhibit the effect of NAC on the production of HSA-pFSHβ.”
The Mechanism of N-acetyl-L-cysteine in Improving the Secretion of Porcine Follicle-Stimulating Hormone in Pichia pastoris.
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