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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
supplement:
Emodin
Research Papers that Mention the Interaction
“Pretreatment with the antioxidant NAC diminished apoptosis and p53 overexpression induced by emodin.”
Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway.“…,emodin significantly increased the levels of ROS and MDA, inhibited both SOD level … ratio in human T cells, whereas co-incubation with the ROS scavenger N-acetylcysteine (NAC, 20 μmol/L) almost completely blocked emodin-induced ER stress … in human T cells, and decreased the caspase cascade-mediated apoptosis.”
“Exposure of SA-NH and FSa tumor cells to 10mM NAC inhibited the ability of 5mGy and Emodin to induce intracellular translocation of survivin and the corresponding altered adaptive survival response.”
Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity.“The ROS scavenger NAC , p38 silencing and Puma silencing impaired the anti-proliferation and apoptosis- inducing effects of emodin.”
ROS/p38/p53/Puma signaling pathway is involved in emodin-induced apoptosis of human colorectal cancer cells.
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