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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
Research Papers that Mention the Interaction
“The NAC and Nrf2 activator oltipraz inhibit the decrease of UCP2 expression induced by Dox.”
Metallothionein prevents doxorubicin cardiac toxicity by indirectly regulating the uncoupling proteins 2.“Ascorbic acid and N-acetylcysteine had modest effects on the protection of doxorubicin-induced cytotoxicity while trolox showed insignificant protective effect.”
“In experimental metastasis assays, we have found a synergistic reduction in the number of lung metastases after treatment with doxorubicin (DOX) and NAC in nude mice.”
“In tumorigenicity and spontaneous metastasis assays, the combined administration of DOX and oral NAC again has shown synergistic effects on the frequency and weight of primary tumors and local recurrences and completely prevented the formation of lung metastases.”
“ NAC treatment inhibited the expression of cleaved caspase-3 in ATC cells, and reduced apoptosis in cells that were pretreated with 1,25(OH)2D3 and ADM.”
“However, N-acetylcysteine increased the cleavage of poly (ADP-ribose) polymerase in the presence of doxorubicin.”
“ N-acetylcysteine prevented phosphorylation of P53 protein that had been induced by doxorubicin.”
“Synergy score of 26 patient-derived cells were evaluated after the combination treatment of doxorubicin and N-acetylcysteine.”
“In addition, pretreatment of H9c2 cells with N‑acetyl‑L‑cysteine , a scavenger of reactive oxygen species (ROS) prior to exposure to DOX , markedly decreased the expression of CRT.”
“To determine whether autophagy is required for chemotherapy-induced senescence, reactive oxygen generation induced by Adriamycin was suppressed by N-acetyl cysteine and glutathione, and the induction of ataxia telangiectasia mutated, p53, and p21 was modulated pharmacologically and/or genetically.”
“We have previously reported that pretreatment of human lymphoblastoid cells with the hydroxyl radical scavenger, N-acetyl cysteine , attenuates doxorubicin-induced DNA damage signalling through the ATM protein kinase.”
“The free …, glutathione and N-acetyl cysteine attenuate the … response to Adriamycin in MCF-7 cells as well as in MDA-MB231 and MCF-7/E6 cells, but protect primarily the … cells, indicating that reactive oxygen is unlikely to be directly responsible for Adriamycin toxicity in breast tumor cells.”
“ N-acetylcysteine significantly decreased the concentration of GM-CSF produced by HFCL/EG treated with ADM.”
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