Possible Interaction: Acetylcysteine and Dopamine

“ NAC could prevent DA auto‐oxidation and tyrosinase‐catalyzed DA oxidation, whereas l‐cysteine could potently abrogate DA auto‐oxidation but could not prevent tyrosinase‐catalyzed DA oxidation.”

“However, both H2O2 scavenging and quinone scavenging properties of N-acetylcysteine probably account for its protective effect against Na+,K+-ATPase inhibition induced by dopamine.”

“This study has shown that N-acetylcysteine (0.25–1 mm) is a potent scavenger of both H2O2 and toxic quinones derived from dopamine and it further prevents dopamine mediated inhibition of Na+,K+-ATPase activity and mitochondrial respiratory chain function.”

“However, a direct action of NAC on the regulation of thiolic groups of the cysteine residues in proteins involved in the disease’s pathogenesis, including the transport and metabolism of dopamine , should not be excluded.”

“We found that the pre-incubation with N-Acetyl-l-Cysteine (a quinone reductase inducer) or Deferoxamine (an iron chelator) prevents the generation of ROS, restores the autophagy degradation of mHtt and preserves the cell viability in SH-SY5Y cells expressing the polyQ Htt and exposed to DA.”

“Conclusions The results of this preliminary study demonstrate for the first time a potential direct effect of NAC on the dopamine system in PD patients, and this observation may be associated with positive clinical effects.”

“After FPN treatment, dopamine (DA) levels decreased significantly in both cell and culture media, and oxidative effects of DA were blocked by NAC pretreatment.”

“It was also demonstrated that the antioxidants, N-acetylcysteine , and Sulforaphane, attenuated the toxicity of the mixture of As(+3) and DA to the SH-SY5Y cells.”

“Addition of an antioxidant, N-acetylcysteine (3 mM), prevented dopamine being expelled from vesicles and inhibited rotenone-induced apoptosis.”

“The influence of DA , but not AD or NA, on chemokine production was completely prevented by the addition of N-acetylcysteine.”

“Our data suggested that dopamine receptivity was reduced in the NAc but increased in the PFC and dopamine-producing VTA.”