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Last Updated: 3 years ago

Possible Interaction: Acetylcysteine and Disulfiram

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supplement:

Acetylcysteine

drug:

Disulfiram

Research Papers that Mention the Interaction

“Hepatocyte toxicity of DSF was potentiated by diethylmaleate (GSH depletor) and inhibited by N-acetylcysteine (GSH biosynthesis precursor).”

Loss of viability after disulfiram treatment without preceding depletion of intracellular GSH.

The Journal of toxicological sciences • 1990 | View Paper

“ Disulfiram , an inhibitor of aldehyde dehydrogenases, but also of microsomal oxidation, also markedly inhibits the excretion of the mercapturic acid , after administration of a single high dose (1 g/kg) or upon chronic treatment with a low dose (50 mg/kg).”

The influence of disulfiram and other inhibitors of oxidative metabolism on the formation of 2-hydroxyethyl-mercapturic acid from 1,2-dibromoethane by the rat.

Biochemical pharmacology • 1981 | View Paper

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