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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Acetylcysteine and Dinoprostone

Research Papers that Mention the Interaction

N:-acetyl-L-cysteine and pyrrolidinedithiocarbamate, two inhibitors of reactive oxygen species (ROS), inhibit NNK-induced PGE2 synthesis by 41 and 44%, respectively.
Carcinogenesis  •  2000  |  View Paper
The antioxidant N-acetylcysteine decreased UVB-induced EGF-R tyrosine phosphorylation and PGE2 synthesis to near-basal levels.
The Journal of biological chemistry  •  1994  |  View Paper
NAC delivered postinjury reduced neuronal death and improved functional recovery at least 7 days following ICH in mice and can synergize with clinically approved prostaglandin E2 (PGE2 ).
Annals of neurology  •  2018  |  View Paper
Pretreatment with N-acetylcysteine NAC ) reduced COX-2 expression and PGE2 release induced by PDT.
Journal of photochemistry and photobiology. B, Biology  •  2014  |  View Paper
NAC (10 mM) inhibited accumulation of PGE2 and IL10 only; NBDI (10 μM) had no significant effect.
Reproduction  •  2014  |  View Paper
Whereas NAC suppressed production of CXCL8 by CSE-conditioned DCs, it augmented production of PGE2 and cellular COX-2 levels in maturing DCs.
Molecular immunology  •  2008  |  View Paper
The pre-treatment of LPS-stimulated PBMCs with NAC resulted in a significant decrease in PGE2 concentration in comparison to the cells treated with LPS alone (PGE2 level was 386.1±61.9pg/mL vs. 2078.9±157.9pg/mL, respectively, p<0.001).
Immunology letters  •  2016  |  View Paper
Similar to the effect of RA, both NAC and NS-398 (COX-2 inhibitor) blocked CoCl2-induced COX-2 expression and PGE2 secretion.
Archives of pharmacal research  •  2014  |  View Paper
Significantly, when combined with NAC, PGE2 extended the time window for a successful intervention, synergistically reducing apoptosis, improving liver enzymes, and preventing death.
Proceedings of the National Academy of Sciences of the United States of America  •  2010  |  View Paper
RESULTS Exposure of the macrophage to the antioxidants vitamin E and NAC inhibited TNF production, accumulation of TNF messenger RNA, procoagulant activity expression, and prostaglandin E2 production.
RESULTS Exposure of the macrophage to the antioxidants vitamin E and NAC inhibited TNF production, accumulation of TNF messenger RNA, procoagulant activity expression, and prostaglandin E2 production.
Surgery  •  1995  |  View Paper
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