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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Acetylcysteine and Dinitrochlorobenzene

Research Papers that Mention the Interaction

A pre-treatment with an antioxidant, N-acetyl-L-cysteine (NAC) markedly reduced Erk1/2 inhibition and p38 MAPK phosphorylation induced by DNCB and thimerosal, suggesting a direct activation of p38 MAPK via an oxidative stress and a regulation of MAPK signalling pathways depending on chemicals.
Toxicology and applied pharmacology  •  2008  |  View Paper
Clotrimazole, a specific inhibitor of the Ca2+ activated potassium (Gardos) channel, and the antioxidant N‐acetylcysteine were found to inhibit the in vitro formation of high‐density sickle cells induced by treatment with 1‐chloro‐2,4‐dinitrobenzene (CDNB).
The CDNB induced leakage of K+ can be inhibited by treatment of SS erythrocytes with 20 mM N‐acetylcysteine.
American journal of hematology  •  1999  |  View Paper
N-Acetylcysteine failed to inhibit DEM- and phorone-mediated induction of these enzymes and the early depletion of GSH content, while it inhibited somewhat these changes produced by CDNB.
Journal of pharmacobio-dynamics  •  1990  |  View Paper