supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Acetylcysteine
Research Papers that Mention the Interaction
“Co‐infusion of N‐acetylcysteine (100 μm) or melatonin (50 μm) increased l‐DOPA (up to 151‐ and 246‐fold, respectively) and decreased l‐DOPA‐SQ (by about 53% and 87%, respectively) dialysate concentrations.”
Endogenous melatonin protects L‐DOPA from autoxidation in the striatal extracellular compartment of the freely moving rat: potential implication for long‐term L‐DOPA therapy in Parkinson's disease“The decrease in cell viability by L‐DOPA (10±4% of control) or dopamine (15±4% of control) was markedly attenuated by antioxidants (ascorbic acid, glutathione, N‐acetyl‐L‐cysteine and sodium metabisulphite).”
“ L‐DOPA auto‐oxidation is inhibited by NAC and enhanced by manganese.”
“intrastriatal infusion of N‐acetylcysteine (NAC) significantly increased DA and L‐DOPA dialysate concentrations and lowered those of L‐DOPA semiquinone; in addition, NAC decreased DOPAC+HVA and uric acid dialysate concentrations.”
“The antioxidant N‐acetyl‐L‐cysteine significantly inhibited decreases in cell viability, apoptosis, and changes in DA metabolism induced by the manganese association with L‐DOPA.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback