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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Acetylcysteine
Research Papers that Mention the Interaction
“Co‐infusion of N‐acetylcysteine (100 μm) or melatonin (50 μm) increased l‐DOPA (up to 151‐ and 246‐fold, respectively) and decreased l‐DOPA‐SQ (by about 53% and 87%, respectively) dialysate concentrations.”
Endogenous melatonin protects L‐DOPA from autoxidation in the striatal extracellular compartment of the freely moving rat: potential implication for long‐term L‐DOPA therapy in Parkinson's disease“The decrease in cell viability by L‐DOPA (10±4% of control) or dopamine (15±4% of control) was markedly attenuated by antioxidants (ascorbic acid, glutathione, N‐acetyl‐L‐cysteine and sodium metabisulphite).”
“ L‐DOPA auto‐oxidation is inhibited by NAC and enhanced by manganese.”
“intrastriatal infusion of N‐acetylcysteine (NAC) significantly increased DA and L‐DOPA dialysate concentrations and lowered those of L‐DOPA semiquinone; in addition, NAC decreased DOPAC+HVA and uric acid dialysate concentrations.”
“The antioxidant N‐acetyl‐L‐cysteine significantly inhibited decreases in cell viability, apoptosis, and changes in DA metabolism induced by the manganese association with L‐DOPA.”
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