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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Acetylcysteine
drug:
Dihydroartemisinin
Research Papers that Mention the Interaction
“Interestingly, pretreatment … an antioxidant N-Acetyle-Cysteine (NAC) significantly prevented the cytotoxicity … the combination treatment of DHA and FTS instead of the combination treatment of ARS and FTS, suggesting that reactive oxygen species (…) played a key role in the anticancer action of the combination treatment of DHA and FTS.”
Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives“ NAC , a ROS inhibitor, partly rescued the combinatorial cytotoxic effect of 968 and DHA.”
“However, N-acetyl cysteine significantly reduced the enhanced apoptosis observed with the combination of DHA and Apo2L/TRAIL.”
“Pretreatment with the antioxidant N-acetylcysteine could attenuate the effects of DHA in the experiments.”
“The radiosensitizing effect of dihydroartemisinin was blocked significantly by the free radical scavengers, NAC and TIRON, indicating association with dihydroartemisinin-induced ROS generation.”
“Cytotoxicity of DHA was suppressed by N-acetylcysteine.”
Dihydroartemisinin Induces Apoptosis in Human Bladder Cancer Cell Lines Through Reactive Oxygen Species, Mitochondrial Membrane Potential, and Cytochrome C Pathway
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