“Hearts treated with diazoxide in the presence of 4 mmol/L NAC recovered 53% of initial left ventricular developed pressure, whereas hearts treated with NAC alone recovered 46% of preischemic function.”
“Using 31P NMR spectroscopy, we found that, similar to preconditioning, diazoxide significantly attenuated ischemia-induced intracellular acidification and enhanced post-ischemic recovery of phosphocreatine levels, both of which were blocked by cotreatment with NAC.”
“We also examined the ability of NAC to block the protective effects of diazoxide in the perfused rat heart.”