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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Diazoxide
Research Papers that Mention the Interaction
“ N-acetylcysteine , but not diphenyleneiodonium, attenuated ERK activation mediated by diazoxide.”
Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism.“This effect of l‐arginine was found to be abolished by the blockade of mito K+ATP channels with 5‐HD and, similarly, the effect of diazoxide was blocked in the presence of a ROS scavenger, NAC.”
Brief femoral artery ischaemia provides protection against myocardial ischaemia–reperfusion injury in rats: the possible mechanisms“ N-Acetylcysteine proved to be an inadequate antioxidant for these tests since it directly interfered with the ability of diazoxide to activate mitoKATP.”
“Hearts treated with diazoxide in the presence of 4 mmol/L NAC recovered 53% of initial left ventricular developed pressure, whereas hearts treated with NAC alone recovered 46% of preischemic function.”
“Using 31P NMR spectroscopy, we found that, similar to preconditioning, diazoxide significantly attenuated ischemia-induced intracellular acidification and enhanced post-ischemic recovery of phosphocreatine levels, both of which were blocked by cotreatment with NAC.”
“We also examined the ability of NAC to block the protective effects of diazoxide in the perfused rat heart.”
“Confocal microscopy revealed that diazoxide also led to nuclear translocation of the transcription factors c-Fos and NFκB, which was also blocked by NAC or 5-HD.”
The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes
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