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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Acetylcysteine
drug:
Deferoxamine
Research Papers that Mention the Interaction
“Addition of deferoxamine or ascorbic acid diminished the formation of the NAC influenced products.”
Novel cytochrome p450 bioactivation of a terminal phenyl acetylene group: formation of a one-carbon loss benzaldehyde and other oxidative products in the presence of N-acetyl cysteine or glutathione.“Isolated use of the antioxidant N-acetylcysteine after induction of sepsis did not increase survival, but use of N-acetylcysteine plus deferoxamine (an iron chelator) did.”
“Furthermore, NAC plus DFX was effective in decreasing the severity and duration of AKI, and patients in the treatment group had lower serum creatinine levels at discharge.”
“The effects of NAC plus DFX could be secondary to the attenuation of early inflammatory response and oxidative damage.”
“Furthermore, the alterations in the cholinergic system were partially prevented by the co-administration of NAC and DFX.”
Antioxidants Reverse the Changes in the Cholinergic System Caused by L-Tyrosine Administration in Rats“CONCLUSIONS Our experimental study showed that coadministration of NAC and DFO during liver hemorrhage can decrease the amounts of fluids needed for resuscitation.”
“Discussion This study demonstrates that mdx muscle cells are able to produce key oxidative stress and inflammatory markers, without the interference of inflammatory cells, and shows that NAC plus DFX reduced the inflammatory and oxidative stress indicators, mainly H2O2 production and NF-κB levels by dystrophic fibers.”
“Treatment with NAC , DFX, or NAC plus DFX significantly decreased H2O2 production (24, 58, and 72%, respectively), and levels of 4-HNE-protein adducts (62, 33, and 71%, respectively), TNF-α (32, 29, and 31%, respectively), and NF-κB (34, 38, and 52%, respectively) on dystrophic muscle cells.”
“We investigated whether deferoxamine (DFX) improves the antioxidant effects of N-acetylcysteine (NAC) on primary cultures of dystrophic muscle cells from mdx mice, the experimental model of DMD.”
“The Nac plus DFX adjunctive treatment prevented both the manic-like behavior and oxidative damage induced by PSD.”
“For instance, septicemia induced accentuation of intra-cranial creatine kinase activity is significantly reduced following the administration of DFX in conjunction with taurine and n-acetylcysteine [11].”
“All these memory impairments were prevented by N-acetylcysteine plus deferoxamine with or without basic support and its isolate use.”
“On the other hand, there was an increase of protein phosphorylation in cortex and N-acetylcysteine plus deferoxamine with or without basic support prevented it.”
“Moreover, the increased AChE activity is prevented by the coadministration of N-acetylcysteine and deferoxamine as antioxidants.”
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