Possible Interaction: Acetylcysteine and Cysteine

“In conclusion, NAC improved performance in well-trained individuals, with enhanced muscle cysteine and GSH availability a likely mechanism.”

“ Muscle cysteine and cystine were unchanged during Con, but were elevated above preinfusion levels with NAC (P <0.001).”

“Acute administration of N-acetylcysteine (NAC) may induce alterations in plasma and urinary levels of homocysteine (Hcy) and cysteine (Cys).”

“ NAC has been suggested to act by raising concentrations of cysteine , and hence glutathione, and by scavenging of oxidant species [1, 11, 17, 29].”

“In cancer cells, we show that NAC treatment produces an increase in specifically labeled reduced thiols of c-Src cysteines , thus confirming a redox transition.”

“Furthermore, treatment with NAC partially reversed the 2DG-induced decreases in total glutathione content, as well as augmented intracellular cysteine content.”

“In the NAC group we also observed an acute increase in dialysate concentrations of cysteine after NAC injection.”

“We found that the Na+ current was increased by mutagenesis or chemical modification of this residue and adjacent … α, β, and γENaC. This resulted from a change in the gating of ENaC; modification of a cysteine at … in βENaC increased the open state probability … 0.12 to 0.96.”

“In various tissues, NAC may increase the levels of glutathione and cysteine and stimulate the superoxide dismutase action.”

“ NAC increases the concentrations of amino acids and their derivatives, including cysteine , cystine, and glutathione.”

“In vitro study show us, the cysteine (Cys) as a prodrug of NAC can decrease the concentration of Cr(VI) in blood samples and human body.”

“However, glutathione (GSH), homocysteine, N-acetyl-L-cysteine and other thiols greatly hamper the detection of Cys.”