Possible Interaction: Acetylcysteine and Cyclosporine

“ NAC , anoxia or metformin prevented the two phases of oxidative stress while CsA prevented the second one only.”

“The apoptotic process was partially inhibited by cyclosporine A and substantially blocked by the antioxidant N-acetylcysteine , suggesting an essential role for reactive oxygen species formation during the apoptotic processes.”

“In addition, TGM-2 induced by CsA is downregulated by PD98059, LY294002, NAC , curcumin, EGCG, and SB203580.”

“The addition of PD98059, LY294002, NAC , curcumin, EGCG, and SB203580 markedly inhibited TGM-2 expression induced by CsA (P <0.05).”

“Co-administration of CsA with the antioxidant N-acetylcysteine significantly decreased lipid peroxidation and also partially corrected the CsA-induced unfolded protein response.”

“We further demonstrated that, with the exception of the statins, all of these anti‐HCV nutrients and reagents actually induced activation of … reduced by treatment not only with U0126 but also with vitamin E. We also demonstrated that phosphorylation of ERK1/2 by cyclosporine A … N‐acetylcysteine treatment … replication.”

“Results Concomitant administration of CsA and NAC significantly improved renal function and attenuated tubulointerstitial fibrosis, and these changes were accompanied by decreased urinary 8-OHdG level and increased MnSOD expression.”

“Concurrent NAC administration with CsA improved renal function, as indicated by lower BUN and Cr values.”

“A significant elevation in serum AST and ALT activities was observed in the CsA group, and when NAC and CsA were co‐administered, the activities of AST and ALT were close to the control levels.”

“CsA administration produced a decrease in hepatic SOD activity, and co‐administration of NAC with CsA resulted in an increase in SOD activity.”

“When CsA was administered to mice, the increased presence of 3-nitrotyrosine was detected in the aortic endothelium, an effect also abrogated by the concomitant administration of NAC.”

“Further, we demonstrate that the antioxidant N-acetyl-l-cysteine blocked the increase in vasopressin type 1A receptor mRNA and protein levels induced by CsA and that low concentrations of prooxidants were able to directly increase vasopressin type 1A receptor mRNA and protein levels.”