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Last Updated: 4 months ago

Possible Interaction: Acetylcysteine and Cyclosporine

Research Papers that Mention the Interaction

In addition, TGM-2 induced by CsA is downregulated by PD98059, LY294002, NAC , curcumin, EGCG, and SB203580.
The addition of PD98059, LY294002, NAC , curcumin, EGCG, and SB203580 markedly inhibited TGM-2 expression induced by CsA (P <0.05).
The addition of PD98059, LY294002, NAC , curcumin, EGCG, and SB203580 markedly inhibited TGM-2 expression induced by CsA (P <0.05).
Journal of periodontology  •  2013  |  View Paper
Co-administration of CsA with the antioxidant N-acetylcysteine significantly decreased lipid peroxidation and also partially corrected the CsA-induced unfolded protein response.
Journal of proteomics  •  2011  |  View Paper
We further demonstrated that, with the exception of the statins, all of these anti-HCV nutrients and reagents actually induced activation of … reduced by treatment not only with U0126 but also with vitamin E. We also demonstrated that phosphorylation of ERK1/2 by cyclosporine A … N-acetylcysteine treatment … replication.
Hepatology  •  2009  |  View Paper
NAC , anoxia or metformin prevented the two phases of oxidative stress while CsA prevented the second one only.
Biochimica et biophysica acta  •  2015  |  View Paper
The apoptotic process was partially inhibited by cyclosporine A and substantially blocked by the antioxidant N-acetylcysteine , suggesting an essential role for reactive oxygen species formation during the apoptotic processes.
Apoptosis  •  2007  |  View Paper
RESULTS Concomitant administration of CsA and NAC significantly improved renal function and attenuated tubulointerstitial fibrosis, and these changes were accompanied by decreased urinary 8-OHdG level and increased MnSOD expression.
RESULTS Concomitant administration of CsA and NAC significantly improved renal function and attenuated tubulointerstitial fibrosis, and these changes were accompanied by decreased urinary 8-OHdG level and increased MnSOD expression.
Transplantation  •  2013  |  View Paper
Concurrent NAC administration with CsA improved renal function, as indicated by lower BUN and Cr values.
Renal failure  •  2008  |  View Paper
When CsA was administered to mice, the increased presence of 3-nitrotyrosine was detected in the aortic endothelium, an effect also abrogated by the concomitant administration of NAC.
Free radical biology & medicine  •  2007  |  View Paper
RESULTS In rVSMCs, LPS increased nitric oxide and iNOS expression; CsA decreased basal and LPS-induced nitric oxide and iNOS expression; NAC increased nitric oxide and blunted the nitric oxide reduction caused by CsA , with no effect on iNOS.
RESULTS In rVSMCs, LPS increased nitric oxide and iNOS expression; CsA decreased basal and LPS-induced nitric oxide and iNOS expression; NAC increased nitric oxide and blunted the nitric oxide reduction caused by CsA , with no effect on iNOS.
Kidney international  •  2005  |  View Paper
Further, we demonstrate that the antioxidant N-acetyl-L-cysteine blocked the increase in vasopressin type 1A receptor mRNA and protein levels induced by CsA and that low concentrations of prooxidants were able to directly increase vasopressin type 1A receptor mRNA and protein levels.
The Journal of biological chemistry  •  2003  |  View Paper