Possible Interaction: Acetylcysteine and Cyclophosphamide

“ N-acetylcysteine reversed the reduction in the GSH/GSSG ratio seen in the doxorubicin and cyclophosphamide-treated rats.”

“The coadministration of cyclophosphamide with N-acetylcysteine has also been investigated.”

“The cystitis due either to cytoxan or acrolein was prevented by simultaneous intravesical administration of an aldehyde inactivating agent, acetylcysteine (mucomyst).”

“The metabolic activation of procarcinogens (aflatoxin B1, 2-aminofluorene, cyclophosphamide , benzo[a]pyrene, a tryptophan pyrolysate product and cigarette smoke condensate) was inhibited by NAC in uninduced rats, while it was further stimulated in Aroclor-pre-treated animals.”

“At a dose of 325 mg/kg orally, acetylcysteine when given together with cyclophosphamide (30 mg/kg i.p.)”

“ N-acetylcysteine increased the number of immune cells and decreased TNF-α production after cyclophosphamide injection and decreased TNF-α, IFN-γ, NF-κB, and IL-8 expression and increased IL-10 expression in peripheral blood mononuclear cells.”

“Serum levels of alanine transaminase and aspartate aminotransferase decreased, superoxide dismutase activity increased, and malondialdehyde activity decreased following N-acetylcysteine treatment after cyclophosphamide injection.”

“The present study examined whether N-acetylcysteine modulates the adverse effects of cyclophosphamide in pigs.”

“ N-acetyl-L-cysteine (NAC) is a powerful antioxidant that may decrease the toxicity of certain anticancer drugs, such as doxorubicin and CP.”

“The data indicate that NAC , a well-tolerated, relatively inexpensive antioxidant, appears to reduce the incidence of specific cyclophosphamide-induced malformations when administered prior to, concurrently with, and after exposure to CP.”

“There were significant reductions in the incidences of digit, limb, and tail defects, as well as anasarca and macroglossia, in fetuses exposed to the combination of NAC and CP , compared to fetuses exposed to CP only.”