supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 years ago
supplement:
Acetylcysteine
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“ N-acetylcysteine induced extensive DNA damage in the presence of Cu(II).”
“The DNA cleavage was enhanced by piperidine treatment, suggesting that N-acetylcysteine plus Cu(II) caused not only deoxyribose phosphate backbone breakage but also base modification.”
“The content of 8-oxodG in calf thymus DNA was increased by N-acetylcysteine in the presence of Cu(II).”
N-acetylcysteine, a cancer chemopreventive agent, causes oxidative damage to cellular and isolated DNA.“Addition into the culture medium … the antioxidant N-acetylcysteine NAC , 1 mM) in the presence of Cu2+ (0.0005-0.001 mM) induced intensive death of cultured rat cerebellar granule neurons, which was significantly decreased by the zinc ion chelator TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine).”
N-acetyl-L-cysteine in the presence of Cu2+ induces oxidative stress and death of granule neurons in dissociated cultures of rat cerebellum“The same compounds, GSH, dithiothreitol, N-acetylcysteine , mercaptopropionylglycine and DL-penicillamine protected the enzyme from inactivation by Cu(II) (Tables 2, 4-6).”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback