Possible Interaction: Acetylcysteine and Copper

“Chicken hepatocytes were cultured in medium in the absence and presence …, 12, and 24 h, and in the combination of CuSO4 and N-acetyl-l-cysteine (NAC) (1 mM), …. Results showed that Cu could markedly increase the number of autophagosomes and …) mRNA expression and proteins (BECN1, LC3Ⅱ/LC3Ⅰ) expression.”

“Finally, we found that ROS scavengers NAC , GSH, and DMTU not only inhibited in vivo ROS levels induced by copper , but also significantly decreased high expression of hemoglobin back to almost normal levels in copper exposed embryos, and also helped with copper elimination from the embryos.”

“In subchronic intoxication via repeated intraperitoneal injection of copper oxide nanoparticles (diameter 20 nm, 19 times in …), findings are that oral intake of bioprotectors complex (pectine, polyvitamin and polymineral preparation, sodium glutaminate, glycine, acetylcysteine and fish oil … group) decreases copper accumulation in viscera (including statistically … liver, brain and kidneys.”

“In conclusion, treatment with N-acetylcysteine modulated the antioxidant redox system and reduced brain oxidative stress induced by copper.”

“The results proved that the use of methanol and N-acetylcysteine increased the activities of Cu ,Zn-superoxide dismutase, glutathione peroxidase and glutathione reductase by about 15,15 and 41%, respectively, in comparison to the group of rats receiving methanol alone.”

“The mortality in animals given copper and treated with NAC was almost eliminated, except at the highest doses.”

“In the field trials, NAC at 1,000 mg liter-1 + copper at 150 mg liter-1 significantly reduced disease severity compared with the untreated control.”

“NAC increased sensitivity of the copper-resistant X. perforans to copper in vitro when … NAC was followed by copper application after 6 h. In greenhouse assays, NAC applied alone … combination with copper significantly (P < 0.05) reduced the disease severity of … spot on tomato compared with the untreated control.”

“Overall, NAC modulates the homeostasis of Cu and Zn both in vitro and in vivo and accordingly affects the cellular redox balance.”

“We showed that NAC treatment reduced the cellular concentration of Zn and Cu.”

“In comparison …, NAC treatment … HMs ( Cu , Cd, Hg and Pb, respectively) stimulated root growth (1.1-, 1.5-, 10.5- and 1.9-fold), and significantly increased fresh (…-, 1.5-, 4.3- and 1.4-fold) and dry (1.2-, 1.5-, 2.5- and 1.2-fold) mass.”

“The fluorescence intensity of N-acetyl-L-cysteine capped CdHgSe quantum dots decreased when interacted with copper ions due to the formation of coordination complex and aggregates.”