Possible Interaction: Acetylcysteine and Cisplatin

“In addition, the activation of JNK signaling pathway prompted by WZ26 and cisplatin was also reversed by NAC pretreatment.”

“More importantly, the application of this research tool has unraveled the mechanisms by which the chemoprotective agents sodium thiosulfate, d-methionine, N-acetyl-cysteine and l-glutathione modulate the metabolism of CP in plasma, namely by rapidly reacting with the MHC to form platinum‑sulfur complexes.”

“For its ability to reduce cisplatin reactivity, in addition to its antioxidant effect, we tested and found that N‐acetylcysteine (NAC) was most effective at inhibiting cisplatin cytotoxicity.”

“ N‐acetylcysteine binds intracellular cisplatin and reduces its reactivity.”

“Pt‐DNA‐binding experiments suggest that the differential effectiveness of NAC is due to its capacity to quench cisplatin reactivity inside the cell.”

“ NAC reduces cisplatin‐induced cognitive impairments.”

“Therapeutic agents, such as N‐acetylcysteine , may be effective in mitigating the deleterious effects of cisplatin.”

“Our previous studies have shown that the chemoprotective agents N-acetyl-l-cysteine and sodium thiosulfate modulate the metabolism of CP in human plasma in vitro, albeit in a different manner.”

“Thus, preincubation with the glutathione inhibitor buthionine sulfoximine (BSO) induced massive cell death, whereas N-acetyl cysteine , a precursor of glutathione synthesis, improved the resistance to cisplatin treatment.”

“Pretreatment with NAC decreased cisplatin efficacy, while 4 h delayed NAC did not significantly affect cisplatin anti-tumor effects (relative tumor volume 6.8 ± 2.0 fold baseline, P < 0.001).”

“The antioxidant N-acetylcysteine significantly reversed the increased renal lipid peroxidation, activated renal caspase cascade, and increased blood BUN and creatinine in cisplatin-alone- or cisplatin plus salubrinal-treated mice.”

“The cytotoxicity caused by AAP plus CDDP was decreased by NAC , with the effectiveness being time-dependent.”

“ Cisplatin toxicity could …-cysteine ( NAC ), or Compound C. Cleaved-Poly-(ADP-ribose) polymerase (cl-PARP) and cleaved-caspase 3 (cl-caspase 3) were downregulated in ANE-treated … Compound C. Collectively, ANE could decrease cisplatin toxicity of OSCC by inducing autophagy, which involves the ROS and AMPK/mTOR signaling pathway.”