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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
drug:
Chloroquine
Research Papers that Mention the Interaction
“In presence of reactive oxygen species inhibitor N-acetyl-L-cysteine ) and autophagy inhibitor ( chloroquine ), T-12 induced tumor regression was significantly decreased.”
Triazole analog 1-(1-benzyl-5-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)-2-(4-bromophenylamino)-1-(4-chlorophenyl)ethanol induces reactive oxygen species and autophagy-dependent apoptosis in both in vitro and in vivo breast cancer models.“In contrast, N-acetyl-cysteine which is expected to increase the cellular levels of GSH, antagonized the action of CQ.”
“Furthermore, using chloroquine and siATG5 significantly enhances ROS production and application of the ROS scavenger N-acetyl-cysteine (NAC) rescues the cells undergoing apoptosis by abrogating the expression of DR5 and finally the caspase cascade.”
“However, an intra‐peritoneal injection of the antioxidant N‐acetyl‐l‐cysteine NAC ) and autophagy inhibitor chloroquine inhibited the inflammatory response, liver damage, and pexophagy in the liver of catalase‐KO mice during prolonged fasting.”
Catalase deficiency induces reactive oxygen species mediated pexophagy and cell death in the liver during prolonged fasting“In contrast, N-acetyl-cysteine which is expected to increase the cellular levels of GSH, antagonized the action of CQ.”
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