Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Acetylcysteine and Capsaicin

supplement:

Acetylcysteine

supplement:

Capsaicin

Research Papers that Mention the Interaction

Moreover, NAC abrogated the effects of capsaicin on Stat3-dependent autophagy.
Free radical research  •  2016  |  View Paper
Co-treatment of cells with NAC and capsaicin abrogated the effects of capsaicin on autophagy and cell death.
Furthermore, we found that capsaicin triggered ROS generation in cells, while the levels of ROS decreased with N-acetyl-cysteine ( NAC ), a ROS scavenger.
Oncotarget  •  2016  |  View Paper
The antioxidant N-acetyl-l-cysteine (NAC) acts synergistically with CAP to reduce ROS generation, without affecting CAP-induced toxicity.
Cellular signalling  •  2014  |  View Paper
The CAP and H2O2-induced TRPM2 current densities were also decreased by the NADPH oxidase inhibitors apocynin and N-Acetylcysteine.
Journal of Molecular Neuroscience  •  2017  |  View Paper
NAC (1 g/kg/d × 7 days) prevented B1R up-regulation, superoxide anion production and NF-kB activation induced by capsaicin (15 mg/kg).
Journal of Neuroinflammation  •  2011  |  View Paper
Our findings confirm a role for the spinal cord in NAC actions because systemic NAC administration also reduced the nociception trigged by intrathecal injection of capsaicin.
Systemic or spinal, but not peripheral, administration of the exogenous thiolic compound N-acetyl-L-cysteine (NAC) reduced nociception induced by intraplantar capsaicin injection.
The journal of pain : official journal of the American Pain Society  •  2010  |  View Paper
In addition, NAC completely blocked phosphorylation of JNK and p38 MAPK induced by capsaicin.
Neoplasma  •  2015  |  View Paper