Possible Interaction: Acetylcysteine and Calcium Supplement

“ N-Acetylcysteine abrogated both reactive oxygen species (ROS) production and viability loss induced by Ca 37 but partially prevented growth inhibition in PC-3 cells treated with curcumin alone, or a combination with Ca 37.”

“Furthermore, an ROS scavenger, N-acetyl-cysteine (NAC), markedly decreased the accumulation of intracellular calcium and apoptosis.”

“ N-acetyl-l-cysteine pretreatment significantly reversed Cuc B-induced DNA damage, increased intracellular calcium ion concentration, and reduced MMP, G2/M phase arrest, and apoptosis.”

“The antioxidant N‐acetylcysteine NAC ) reduced ROS accumulation, MMP and Ca i2+ surge, on the other hand the Ca2+ chelator BAPTA inhibited the Ca i2+ overload and MMP without affecting the increase of ROS, indicating that the generation of ROS occurred prior to Ca2+ flux.”

“The use of NAC inhibited the changes in urine output, pO2, tissue activity of MPO and MDA in pancreas and lungs, and the serum activity of IL-6, ALT, and serum concentrations of urea and calcium.”

“ N-Acetylcysteine blocked calcium accumulation and abolished liver damage by acetaminophen.”

“Moreover, endoplasmic reticulum stress inhibitor (salubrinal) and antioxidant NAC were able to reduce ROS and calcium levels to recover cell viability.”

“These results were supported by the finding that Ca2+ -induced MPT was inhibited by antioxidants, such as glutathione and N-acetylcysteine.”