Possible Interaction: Acetylcysteine and Buthionine Sulfoximine

“Au, BSO and radiation also significantly decreased breast cancer cell migration and invasion in a thiol-dependent manner that could be inhibited by NAC.”

“We found that apoptosis was greatly enhanced by BSO , blocked by NAC , and accompanied by poly(ADP-ribose) polymerase cleavage and activation of caspase-3, caspase-8, and caspase-9.”

“Cotreatment with N-acetyl-l-cysteine , a GSH precursor, ameliorated LCA toxicity, whereas cotreatment with buthionine sulfoximine , a GSH synthesis blocker, exacerbated it.”

“The dialysate concentrations of both glutathione and cysteine decreased during concomitant treatment with BSO and NAC or OTC.”

“ BSO potentiated the observed effect on α1-AR while NAC ameliorated these effects.”

“Strikingly, co-treatment of MSCs with NAC (5 mM) and BSO + 6-OHDA significantly reduced the expression of OS and cell death markers but were unable to restore the expression of GPX1 compared to the expression in untreated or treated cells with NAC only.”

“However, NAC was still able to block z-FA-CMK toxicity in Jurkat T cells in the presence of BSO , indicating that the protective effect of NAC does not involve GSH biosynthesis.”

“Treatment of HTLA-Chr cells with L-Buthionine-sulfoximine , an inhibitor of GSH biosynthesis, markedly reduces their tumorigenic potential that is instead enhanced by the exposure to N-Acetylcysteine , able to promote GSH synthesis.”

“Combinational drug treatment with N-Acetyl-L-cysteine and L-buthioninesulfoximine strongly counteracted effect of 1 and 2, while the same treatment rather enhanced cytotoxicity of Pt(IV) analogues.”

“Inversely, pre-treatment of cells with BSO augmented N-Me-α-MeDA-induced neurotoxicity, but only slightly affected NAC neuroprotection.”