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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Acetylcysteine
supplement:
Bromelains
Research Papers that Mention the Interaction
“ N-acetylcysteine , penicillamine and cysteine ethyl ester … the debriding action of bromelain (an enzymatic preparation from pineapple stems) and in higher concentrations, N-acetylcysteine and penicillamine (cysteine ethyl ester was not … burn eschar from the underlying tissue before solubilization of the eschar is complete (rat) or has occurred (pig).”
Chemical debridement of burns: mercaptans.“ Bromelain and Acetylcysteine (BromAc) has synergistic action against glycoproteins by breakage of glycosidic linkages and disulfide bonds.”
“MethodsThe growth-inhibitory effects of bromelain and N-acetylcysteine , on their own and in combination, on a panel of human gastrointestinal carcinoma cell lines, including MKN45, KATO-III, HT29-5F12, HT29-5M21 and LS174T, were assessed by sulforhodamine B assay.”
“Fraction 3 or bromelain only showed thrombolytic activity in combination with N-acetylcysteine.”
Comparison of proteolytic, cytotoxic and anticoagulant properties of chromatographically fractionated bromelain to un-fractionated bromelain.“ Bromelain with NAC showed synergy in all tumour cell lines and acting synergistically with chemotherapeutic drugs.”
“For bromelain and N-acetylcysteine , certain ratio of the two agents gave very good synergy that was prevalent in almost all cell lines.”
“Hence, we investigated how the drugs potency can be increased by combining with bromelain and N-acetylcysteine.”
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