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Last Updated: 4 years ago

Possible Interaction: Acetylcysteine and Bortezomib

supplement:

Acetylcysteine

Research Papers that Mention the Interaction

Sodium ascorbate and N-acetyl-L-cysteine , but not vitamin B12, completely reversed the cytotoxicity of bortezomib.
AntiCancer Research  •  2020  |  View Paper
Furthermore, BTZ significantly increased the intracellular ROS generation induced by IFNβ gene transfer in melanoma cells, an effect that was reversed by the addition of the ROS inhibitor N-acetyl-L-cystein.
Anti-cancer agents in medicinal chemistry  •  2017  |  View Paper
Pretreatment with the antioxidant N-acetyl-L-cysteine scavenges mitochondrial ROS and decreases cell death after treatment with bortezomib plus 2ME in KMS20 cells.
Experimental & Molecular Medicine  •  2013  |  View Paper
Bortezomib caused an increase in intracellular reactive oxygen species (ROS) and treatment with the ROS scavenger NAC inhibited phosphorylation of ATM leading to a decrease in the number of cells in G2-M phase.
International journal of oncology  •  2012  |  View Paper
N-acetyl-L-cysteine (L-NAC), a ROS scavenger, alleviated oxidative stress and inhibited the apoptosis induced by bortezomib.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2012  |  View Paper
The delayed addition of vitamin C and/or NAC after the exposure to bortezomib alleviated the cytotoxicity in Schwann cells but not myeloma cells.
International journal of hematology  •  2011  |  View Paper