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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Acetylcysteine and Beta-Lapachone

Research Papers that Mention the Interaction

Nuclear magnetic resonance analyses indicated that prevention of β-lapachone derivative cytotoxicity was the result of direct modification of these derivatives by N-acetyl-l-cysteine , preventing their conversion to β-lapachone.
Clinical Cancer Research  •  2005  |  View Paper
N-acetyl-L-cysteine (NAC), a thiol antioxidant, inhibited the apoptosis in DU145 cells after 12 h exposure to beta-lapachone.
Molecular pharmacology  •  2001  |  View Paper
Because reducing agents (dithiothreitol and N-acetylcysteine ) reversed the effect of beta-lapachone , it suggests the role of a critical sulfhydryl group.
Biochemical pharmacology  •  1999  |  View Paper
Again, the beta-lapachone-induced monocytic differentiation was suppressed by NAC.
Free radical biology & medicine  •  1998  |  View Paper