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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Acetylcysteine and Beta-Lapachone

supplement:

Acetylcysteine

drug:

Beta-Lapachone

Research Papers that Mention the Interaction

“Nuclear magnetic resonance analyses indicated that prevention of β-lapachone derivative cytotoxicity was the result of direct modification of these derivatives by N-acetyl-l-cysteine , preventing their conversion to β-lapachone.”
Development of β-Lapachone Prodrugs for Therapy Against Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase 1 Levels
Clinical Cancer Research  •  2005  |  View Paper
“ N-acetyl-L-cysteine (NAC), a thiol antioxidant, inhibited the apoptosis in DU145 cells after 12 h exposure to beta-lapachone.”
Induction of CDK inhibitors (p21(WAF1) and p27(Kip1)) and Bak in the beta-lapachone-induced apoptosis of human prostate cancer cells.
Molecular pharmacology  •  2001  |  View Paper
“Because reducing agents (dithiothreitol and N-acetylcysteine ) reversed the effect of beta-lapachone , it suggests the role of a critical sulfhydryl group.”
Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone.
Biochemical pharmacology  •  1999  |  View Paper
“Again, the beta-lapachone-induced monocytic differentiation was suppressed by NAC.”
Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone-induced apoptosis and differentiation in human leukemia cells.
Free radical biology & medicine  •  1998  |  View Paper